Core Facility Platform for Mass Spectrometry-Based Multi-Omics
Principal Investigator: Associate Professor Wei-Hsiang Chang
Graduate Institute of Food Safety and Risk Management
Background and Rationale
The Core Facility Platform for Mass Spectrometry-Based Multi-Omics was established to advance cutting-edge research in life sciences and biomedicine. Mass spectrometry enables rapid and sensitive identification and quantification of proteins and small-molecule metabolites, offering crucial insights into molecular expression, post-translational modifications, and regulatory mechanisms under diverse biological conditions.
As genome sequencing technologies continue to mature and an increasing number of genomes are decoded, proteomics and metabolomics have emerged as pivotal disciplines in the post-genomic era. In response to strong internal research demands and limited external service availability, our university founded this platform to provide dedicated, high-quality support for multi-omics studies.
Mission and Objectives
The platform aims to establish a comprehensive technological infrastructure based on diverse mass spectrometry applications, encompassing proteomics, peptidomics, and metabolomics. Beginning in late 2024, the facility will deliver specialized analytical services while functioning as an open, shared experimental hub.
In addition to technical support, the platform will host regular training workshops on sample preparation and large-scale multi-omics data analysis. Through these initiatives, we are committed to enhancing both research capacity and academic excellence across the university.
Services Offered
Metabolomics
•Targeted metabolite profiling (e.g., amino acids, short-chain fatty acids, TCA cycle intermediates, disease-related biomarkers)
•Untargeted metabolome profiling (polar metabolites, non-polar metabolites, lipidomics)
Proteomics
•Protein identification
•Post-translational modification analysis
•Quantitative proteomics (data-dependent and data-independent approaches)
•Phosphoproteomics
•Targeted peptide quantification
Bioinformatics and Data Analysis
•Protein database search and identification
•Differential protein expression analysis
•Metabolite database search and identification
•Differential metabolite expression analysis
Graduate Institute of Food Safety and Risk Management
Background and Rationale
The Core Facility Platform for Mass Spectrometry-Based Multi-Omics was established to advance cutting-edge research in life sciences and biomedicine. Mass spectrometry enables rapid and sensitive identification and quantification of proteins and small-molecule metabolites, offering crucial insights into molecular expression, post-translational modifications, and regulatory mechanisms under diverse biological conditions.
As genome sequencing technologies continue to mature and an increasing number of genomes are decoded, proteomics and metabolomics have emerged as pivotal disciplines in the post-genomic era. In response to strong internal research demands and limited external service availability, our university founded this platform to provide dedicated, high-quality support for multi-omics studies.
Mission and Objectives
The platform aims to establish a comprehensive technological infrastructure based on diverse mass spectrometry applications, encompassing proteomics, peptidomics, and metabolomics. Beginning in late 2024, the facility will deliver specialized analytical services while functioning as an open, shared experimental hub.
In addition to technical support, the platform will host regular training workshops on sample preparation and large-scale multi-omics data analysis. Through these initiatives, we are committed to enhancing both research capacity and academic excellence across the university.
Services Offered
Metabolomics
•Targeted metabolite profiling (e.g., amino acids, short-chain fatty acids, TCA cycle intermediates, disease-related biomarkers)
•Untargeted metabolome profiling (polar metabolites, non-polar metabolites, lipidomics)
Proteomics
•Protein identification
•Post-translational modification analysis
•Quantitative proteomics (data-dependent and data-independent approaches)
•Phosphoproteomics
•Targeted peptide quantification
Bioinformatics and Data Analysis
•Protein database search and identification
•Differential protein expression analysis
•Metabolite database search and identification
•Differential metabolite expression analysis